Scientific CMOS Imagers
Objectives: To design and implement scientific CMOS imagers with unique capabilities (e.g. high dynamic range, lifetime measurement) for medical diagnostic and sensing applications
Approach: Many diagnostic and sensing applications have unique needs such as low noise, high dynamic range and the ability to extract both intensity and lifetime from the fluorophore. We have also designed imagers with high dynamic range using linear-log hybrid readout circuitry. Lifetime and phase measurements were achieved using direct phase digitization using comparators and time to digital conversion. For low noise performance, we proposed a uniquw multi-cycle charge modulation technique that acquires photons over multiple cycles of integration. We have also demonstrated many successful pixel level digitizers in our CMOS imagers.
Sample Publications:
1. A 65nm CMOS digital phase imager for time-resolved fluorescence imaging, IEEE Journal of Solid State Circuits, vol. 47, no.7, pp. 1731-1742, July 2012 (invited).
2. CMOS fluorometer for oxygen sensing, IEEE Sensors Journal, vol. 12, no. 7, pp. 2506-2507, vol.12, no.7, pp. 2506-2507, July 2012.
3. A high dynamic range CMOS image sensor for scientific imaging applications”, IEEE Sensors Journal, vol. 9, no. 10, pp. 1209 – 1218, 2009.
4. M. Design, implementation and field testing of portable fluoroscense-based vapor sensor”, Analytical Chemistry, vol.81, no. 13, pp. 5281-5290, 2009.
5. A CMOS Luminescence Intensity and Lifetime Dual Sensor Based on Multicycle Charge Modulation. IEEE transactions on biomedical circuits and systems, 2018.
Approach: Many diagnostic and sensing applications have unique needs such as low noise, high dynamic range and the ability to extract both intensity and lifetime from the fluorophore. We have also designed imagers with high dynamic range using linear-log hybrid readout circuitry. Lifetime and phase measurements were achieved using direct phase digitization using comparators and time to digital conversion. For low noise performance, we proposed a uniquw multi-cycle charge modulation technique that acquires photons over multiple cycles of integration. We have also demonstrated many successful pixel level digitizers in our CMOS imagers.
Sample Publications:
1. A 65nm CMOS digital phase imager for time-resolved fluorescence imaging, IEEE Journal of Solid State Circuits, vol. 47, no.7, pp. 1731-1742, July 2012 (invited).
2. CMOS fluorometer for oxygen sensing, IEEE Sensors Journal, vol. 12, no. 7, pp. 2506-2507, vol.12, no.7, pp. 2506-2507, July 2012.
3. A high dynamic range CMOS image sensor for scientific imaging applications”, IEEE Sensors Journal, vol. 9, no. 10, pp. 1209 – 1218, 2009.
4. M. Design, implementation and field testing of portable fluoroscense-based vapor sensor”, Analytical Chemistry, vol.81, no. 13, pp. 5281-5290, 2009.
5. A CMOS Luminescence Intensity and Lifetime Dual Sensor Based on Multicycle Charge Modulation. IEEE transactions on biomedical circuits and systems, 2018.