Point of care diagnostics
Distance-based paper-based analytical devices (dPADs)
1. Paper-based platforms: As part of our research effort on paper diagnostics for the developing world, we made one of a kind 3D origami paper-analytical device for multiplexed electrochemical sensing for measurement of biomarkers (e.g. pH, dopamine, glucose) in biological fluids. We were also the first to demonstrate nanowire growth on paper substrate to realize high surface area electrodes. We used such electrodes to implement a first of its kind self-powered paper-battery that harvests stomach acid as electrolyte for ingestible electronics.
Storetrack is a skin wearable device for continuous, real-time management of stroke. Utilizing a minimally invasive transdermal patch integrated with a sensing strip, this technology offers critical insights into stress response, inflammation, and neurogenesis following stroke treatment. By enabling early detection, it can guide timely interventions with tailored therapeutics improving stroke recovery and reducing health risks. With its high sensitivity, accuracy, and user-friendly design, this device provides a reliable, cost-effective solution for point-of-care monitoring, even by non-specialists at home. Furthermore, its adaptable platform can be extended to detect other markers of neurological disorders and inflamatory syndromes such.as inflammatory cytokines (IL-6, TNF-α, CRP), neurotrophic factors (BDNF), oxidative stress indicators (MDA, 8-OHdG), and neural damage markers (NSE, S100B).
Following figure shows visual monitoring of Cortisol and Dopamine for proof of concept.
Storetrack is a skin wearable device for continuous, real-time management of stroke. Utilizing a minimally invasive transdermal patch integrated with a sensing strip, this technology offers critical insights into stress response, inflammation, and neurogenesis following stroke treatment. By enabling early detection, it can guide timely interventions with tailored therapeutics improving stroke recovery and reducing health risks. With its high sensitivity, accuracy, and user-friendly design, this device provides a reliable, cost-effective solution for point-of-care monitoring, even by non-specialists at home. Furthermore, its adaptable platform can be extended to detect other markers of neurological disorders and inflamatory syndromes such.as inflammatory cytokines (IL-6, TNF-α, CRP), neurotrophic factors (BDNF), oxidative stress indicators (MDA, 8-OHdG), and neural damage markers (NSE, S100B).
Following figure shows visual monitoring of Cortisol and Dopamine for proof of concept.
Sample Publications:
- A high-density nanowire electrode on paper for biomedical applications. RSC Advances, 5(12), 8680-8687, 2015.
- A three-dimensional electrochemical paper-based analytical device for low-cost diagnostics. Analyst, 143(5), 1059-1064, 2018.
